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KMID : 0043319910140040298
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Archives of Pharmacal Research
1991 Volume.14 No. 4 p.298 ~ p.304
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Microencapsulation of Isoprinosine with Ethylcellulose
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Kim CK
Hwang SJ
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Abstract
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Isoprinosine, an antiviral agent with a bitter taste, has been clinically used up to a maximum of 4g daily in 4-8 doses. In this investigation, isoprinosine was microencapsulated with ethylcellulose 22cps, 50cps and 100cps by means of polymer deposition from cyclohexane through temperature change. Complete removal of cyclohexane from the microcapsules was necessary, since ethylcellulose-coated microcapsules obtained from cyclohexane medium were heavily solvated with cyclohexane and formed lumps even after drying. The displacement of cyclohexane by n-hexane during isolation of microcapsules (Method III) or the freezing of the final-washed microcapsules before drying (Method II) provided the dried products which were more discrete microcapsules than those which were simply dried in the air overnight (Method I). Method III was especially the most effective procedure in preparing finer and more discrete microcapsules. The drug-release from microcapsules was influenced by the ratio of core to wall, the viscosity grade of ethylcellulose and the overall microcapsule size. The release rate was adequately fitted to both the first-order and the diffusion-controlled processes. It is therefore possible to design the release-controlled microcapsules with ethylcellulose of different viscosity along with various core to wall ratio.
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